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pubmed-article:17406009pubmed:abstractTextBy simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.lld:pubmed
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pubmed-article:17406009pubmed:articleTitleFat flies expanded the hippo pathway: a matter of size control.lld:pubmed
pubmed-article:17406009pubmed:affiliationDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.lld:pubmed
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