Linked Life Data

17392735

Source:http://linkedlifedata.com/resource/pubmed/id/17392735

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pubmed-article:17392735pubmed:dateCreated2007-11-16lld:pubmed
pubmed-article:17392735pubmed:abstractTextThe goal of the present study was to investigate the role of environmental context and drug history in modulating the effects of heroin on locomotor activity and Fos protein expression in the neocortex and striatal complex of the rat. It was found that (1) repeated i.p. administrations of a relatively low dose of heroin (1 mg/kg, i.p.) induced psychomotor sensitization only when the treatment was administered in a relatively 'novel' environment (ie, a unique test environment distinct from the home cage) but not when the same treatment was administered in the home cage; (2) environmental novelty facilitated heroin-induced Fos expression in the caudate, particularly in its most caudal regions; (3) environmental context also modulated heroin-induced Fos expression in the nucleus accumbens and in the neocortex; (4) repeated exposures to heroin dramatically altered its effects on Fos expression in the caudate and in the neocortex; and (5) Fos protein levels in the postero-dorsal caudate, in the shell of the nucleus accumbens, and in the barrel field cortex predicted most of the variance in heroin-induced activity scores, as shown by multiple regression analysis. The present report demonstrates that environment and drug history powerfully interact in shaping the neurobehavioral response to heroin, as previously shown for amphetamine and cocaine. Thus, a full understanding of the mechanisms responsible for the neurobehavioral adaptations produced by addictive drugs will also require taking into due consideration the environment in which drugs are experienced.lld:pubmed
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pubmed-article:17392735pubmed:pagination2611-23lld:pubmed
pubmed-article:17392735pubmed:dateRevised2011-5-18lld:pubmed
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pubmed-article:17392735pubmed:year2007lld:pubmed
pubmed-article:17392735pubmed:articleTitleModulatory effect of environmental context and drug history on heroin-induced psychomotor activity and fos protein expression in the rat brain.lld:pubmed
pubmed-article:17392735pubmed:affiliationDepartment of Human Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy.lld:pubmed
pubmed-article:17392735pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17392735pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed