| pubmed-article:1739122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C0680220 | lld:lifeskim |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C0085400 | lld:lifeskim |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:1739122 | lifeskim:mentions | umls-concept:C2362547 | lld:lifeskim |
| pubmed-article:1739122 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1739122 | pubmed:dateCreated | 1992-3-18 | lld:pubmed |
| pubmed-article:1739122 | pubmed:abstractText | The presence of dystrophic neurites in most extracellular neurofibrillary tangles (E-NFT) suggests a factor promoting neurite growth in E-NFT. Although the beta-protein detected in E-NFT may fill that role, reports that only 2-10% of E-NFT contain beta-protein whereas 80-100% contain dystrophic neurites suggested that beta-protein does not play an important role. In this study, the authors used two antisera and one monoclonal antibody to beta-protein to establish the effects of tissue preparation and formic acid enhancement on the detection of beta-protein in E-NFT. We found that beta-protein epitopes in E-NFT are sensitive to formaldehyde fixation and are best enhanced by 50% formic acid, whereas beta-protein in senile plaques is best enhanced at higher formic acid concentrations. After treatment with 50% formic acid, beta-protein was found in all E-NFT. Interestingly, after treatment with 10% formic acid, half of intraneuronal-NFT (I-NFT) also contained beta-protein immunoreactivity. The finding that beta-protein immunoreactivity in senile plaques, E-NFT and I-NFT is increased at different formic acid concentrations suggests that beta-protein in each location is in a different conformation. In contrast, no beta-protein immunoreactivity could be found in E-NFT of the brain stem, an area in which dystrophic neurites do not infiltrate E-NFT. These findings indicate a correlation between neuritic infiltration and presence of beta-protein in E-NFT and suggests the two are linked in Alzheimer's disease for E-NFT as well as senile plaques. | lld:pubmed |
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| pubmed-article:1739122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1739122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739122 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1739122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1739122 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1739122 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:1739122 | pubmed:author | pubmed-author:KawaiMM | lld:pubmed |
| pubmed-article:1739122 | pubmed:author | pubmed-author:PerryGG | lld:pubmed |
| pubmed-article:1739122 | pubmed:author | pubmed-author:CrasPP | lld:pubmed |
| pubmed-article:1739122 | pubmed:author | pubmed-author:TabatonMM | lld:pubmed |
| pubmed-article:1739122 | pubmed:author | pubmed-author:SiedlakS LSL | lld:pubmed |
| pubmed-article:1739122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1739122 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:1739122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1739122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1739122 | pubmed:pagination | 283-90 | lld:pubmed |
| pubmed-article:1739122 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:1739122 | pubmed:meshHeading | pubmed-meshheading:1739122-... | lld:pubmed |
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| pubmed-article:1739122 | pubmed:meshHeading | pubmed-meshheading:1739122-... | lld:pubmed |
| pubmed-article:1739122 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1739122 | pubmed:articleTitle | Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. | lld:pubmed |
| pubmed-article:1739122 | pubmed:affiliation | Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106-4901. | lld:pubmed |
| pubmed-article:1739122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1739122 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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