| pubmed-article:17362008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17362008 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17362008 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:17362008 | lifeskim:mentions | umls-concept:C1517336 | lld:lifeskim |
| pubmed-article:17362008 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:17362008 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:17362008 | pubmed:dateCreated | 2007-4-4 | lld:pubmed |
| pubmed-article:17362008 | pubmed:abstractText | The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit. | lld:pubmed |
| pubmed-article:17362008 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17362008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17362008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17362008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17362008 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17362008 | pubmed:issn | 0002-7863 | lld:pubmed |
| pubmed-article:17362008 | pubmed:author | pubmed-author:PatelDinshaw... | lld:pubmed |
| pubmed-article:17362008 | pubmed:author | pubmed-author:PhanAnh... | lld:pubmed |
| pubmed-article:17362008 | pubmed:author | pubmed-author:NeidleStephen... | lld:pubmed |
| pubmed-article:17362008 | pubmed:author | pubmed-author:KuryavyiVital... | lld:pubmed |
| pubmed-article:17362008 | pubmed:author | pubmed-author:BurgeSarahS | lld:pubmed |
| pubmed-article:17362008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17362008 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17362008 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:17362008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17362008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17362008 | pubmed:pagination | 4386-92 | lld:pubmed |
| pubmed-article:17362008 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:meshHeading | pubmed-meshheading:17362008... | lld:pubmed |
| pubmed-article:17362008 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17362008 | pubmed:articleTitle | Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. | lld:pubmed |
| pubmed-article:17362008 | pubmed:affiliation | Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. phantuan@ntu.edu.sg | lld:pubmed |
| pubmed-article:17362008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17362008 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17362008 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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