| pubmed-article:17360708 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C0071649 | lld:lifeskim |
| pubmed-article:17360708 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:17360708 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:17360708 | pubmed:dateCreated | 2007-4-30 | lld:pubmed |
| pubmed-article:17360708 | pubmed:abstractText | Anthocyanins are a group of naturally occurring phenolic compounds widely available in fruits and vegetables in human diets. They have broad biological activities including anti-mutagenesis and anticarcinogenesis, which are generally attributed to their antioxidant activities. We studied the effects and the mechanisms of the most common type of anthocyanins, cyanidin-3-rutinoside, in several leukemia and lymphoma cell lines. We found that cyanidin-3-rutinoside extracted and purified from the black raspberry cultivar Jewel induced apoptosis in HL-60 cells in a dose- and time-dependent manner. Paradoxically, this compound induced the accumulation of peroxides, which are involved in the induction of apoptosis in HL-60 cells. In addition, cyanidin-3-rutinoside treatment resulted in reactive oxygen species (ROS)-dependent activation of p38 MAPK and JNK, which contributed to cell death by activating the mitochondrial pathway mediated by Bim. Down-regulation of Bim or overexpression of Bcl-2 or Bcl-x(L) considerably blocked apoptosis. Notably, cyanidin-3-rutinoside treatment did not lead to increased ROS accumulation in normal human peripheral blood mononuclear cells and had no cytotoxic effects on these cells. These results indicate that cyanidin-3-rutinoside has the potential to be used in leukemia therapy with the advantages of being widely available and selective against tumors. | lld:pubmed |
| pubmed-article:17360708 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17360708 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17360708 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360708 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17360708 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17360708 | pubmed:month | May | lld:pubmed |
| pubmed-article:17360708 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:NiHong-MinHM | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:YinXiao-MingX... | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:HaradaHisashi... | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:ShurinMichael... | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:TourkovaIrina... | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:WangShiow YSY | lld:pubmed |
| pubmed-article:17360708 | pubmed:author | pubmed-author:FengRentianR | lld:pubmed |
| pubmed-article:17360708 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17360708 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:17360708 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:17360708 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17360708 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17360708 | pubmed:pagination | 13468-76 | lld:pubmed |
| pubmed-article:17360708 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:17360708 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17360708 | pubmed:articleTitle | Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. | lld:pubmed |
| pubmed-article:17360708 | pubmed:affiliation | Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. | lld:pubmed |
| pubmed-article:17360708 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17360708 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17360708 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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