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pubmed-article:17360000pubmed:abstractTextDespite progress in immunosuppression, acute humoral rejection (AHR) remains an unsolved issue in transplantation, with a possible reversibility in only about 50% of cases. AHR is characterized by antidonor antibodies in the recipient circulation and characteristic histological lesions within the graft itself, as well as complement degradation products and immunoglobulins (IgM and IgG) deposition in vascular zones. The lack of a large animal models of AHR in experimental allotransplantation led us to establish such a model in the pig.lld:pubmed
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pubmed-article:17360000pubmed:articleTitleAcute humoral rejection of renal transplants in alloimmunized pigs.lld:pubmed
pubmed-article:17360000pubmed:affiliationINSERM Unit 643 Immunointervention in Allo and Xenotransplantation and ITERT (Institut de Transplantation et de Recherche en Transplantation), Nantes, France.lld:pubmed
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