| pubmed-article:17359298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C0013485 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C0110613 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17359298 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:17359298 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17359298 | pubmed:dateCreated | 2007-3-15 | lld:pubmed |
| pubmed-article:17359298 | pubmed:abstractText | Embryonic stem (ES) cells and embryonal carcinoma (EC) cells express high amounts of functional connexin43 (Cx43). During mesoderm formation and subsequent cardiac differentiation, Cx43 is initially down-regulated but is up-regulated again as the emerging cardiomyocytes mature. In this study, we investigated the regulation of Cx43 expression during early phases of differentiation in F9 and P19 EC cells. We found a striking inverse correlation between the expression of Cx43 and that of the transcriptional repressor Snail1. No clear relationship was found with Smad-interacting-protein1 (SIP1), another transcription factor inducing epithelium-to-mesenchyme transition (EMT). Promoter-reporter assays indicated Cx43 repression at the promoter level by ectopically expressed Snail1. To establish whether the Cx43 down-regulation depends on endogenous Snail1, MES-1 cells, differentiated derivatives of P19 EC, were stably transfected by an siRNA construct silencing Snail1 expression. This resulted in a mesenchyme-to-epithelium transition, which was accompanied by increased levels of Cx43 mRNA and protein and enhanced metabolic and electrical coupling. We conclude that Snail1-mediated EMT results in a Cx43 repression. | lld:pubmed |
| pubmed-article:17359298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17359298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17359298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17359298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17359298 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17359298 | pubmed:issn | 0301-4681 | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:DoevendansPie... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:RookMartin... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:BierhuizenMar... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:VosMarc AMA | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:KokBartB | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:de BoerTeun... | lld:pubmed |
| pubmed-article:17359298 | pubmed:author | pubmed-author:BoonenKristel... | lld:pubmed |
| pubmed-article:17359298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17359298 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17359298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17359298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17359298 | pubmed:pagination | 208-18 | lld:pubmed |
| pubmed-article:17359298 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
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| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:meshHeading | pubmed-meshheading:17359298... | lld:pubmed |
| pubmed-article:17359298 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17359298 | pubmed:articleTitle | Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor. | lld:pubmed |
| pubmed-article:17359298 | pubmed:affiliation | Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:17359298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17359298 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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