| pubmed-article:17342317 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C0142812 | lld:lifeskim |
| pubmed-article:17342317 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:17342317 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17342317 | pubmed:dateCreated | 2007-3-7 | lld:pubmed |
| pubmed-article:17342317 | pubmed:abstractText | Hypoxia-inducible factor-1 (HIF-1) plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumors. Here, we found that a histone deacetylase inhibitor, sodium butyrate, inhibits the hypoxia-induced induction and activity of HIF-1alpha in HT1080 human fibrosarcoma cells. Moreover, sodium butyrate also suppressed the hypoxia-stimulated angiogenic effects and downregulated HIF-1alpha and vascular endothelial growth factor expression in vascular endothelial cells. These findings suggest that sodium butyrate may play important roles in tumor suppression via inhibition of HIF-1alpha mediated angiogenesis under hypoxic conditions. | lld:pubmed |
| pubmed-article:17342317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17342317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17342317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17342317 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17342317 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:17342317 | pubmed:author | pubmed-author:KimKyu-WonKW | lld:pubmed |
| pubmed-article:17342317 | pubmed:author | pubmed-author:JeongJoo-WonJ... | lld:pubmed |
| pubmed-article:17342317 | pubmed:author | pubmed-author:KimSe-HeeSH | lld:pubmed |
| pubmed-article:17342317 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17342317 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17342317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17342317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17342317 | pubmed:pagination | 793-7 | lld:pubmed |
| pubmed-article:17342317 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:meshHeading | pubmed-meshheading:17342317... | lld:pubmed |
| pubmed-article:17342317 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17342317 | pubmed:articleTitle | Inhibition of hypoxia-induced angiogenesis by sodium butyrate, a histone deacetylase inhibitor, through hypoxia-inducible factor-1alpha suppression. | lld:pubmed |
| pubmed-article:17342317 | pubmed:affiliation | Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. | lld:pubmed |
| pubmed-article:17342317 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17342317 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17342317 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17342317 | lld:pubmed |
