| pubmed-article:17339440 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17339440 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:17339440 | lifeskim:mentions | umls-concept:C0012737 | lld:lifeskim |
| pubmed-article:17339440 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17339440 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:17339440 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17339440 | pubmed:dateCreated | 2007-3-6 | lld:pubmed |
| pubmed-article:17339440 | pubmed:abstractText | T-bet is a transcription factor of the T-box family that regulates the expression of numerous immune system-associated genes. T-bet directs the acquisition of the Th1-associated genetic program in differentiating CD4(+) lymphocytes. It also influences the development of NK and NKT cells through its regulation of the IL-2/IL-15Rbeta-chain (CD122) and the trafficking of these lymphocytes through CxCR3. The temporal requirements of T-bet activity for the production of IFN-gamma and the regulation of CD122 and CxCR3 expression remain undefined. We produced an ectopically controllable form of T-bet by fusing its C-terminal domain with a mutated ligand-binding domain of human estrogen receptor alpha. By temporally controlling the expression of T-bet-estrogen receptor alpha by the addition or removal of 4-hydroxytamoxifen (4-HT), we show that IFN-gamma, CD122, and CxCR3 are direct gene targets of T-bet whose expression are acutely regulated by T-bet activity. | lld:pubmed |
| pubmed-article:17339440 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17339440 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339440 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17339440 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17339440 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17339440 | pubmed:author | pubmed-author:GapinLaurentL | lld:pubmed |
| pubmed-article:17339440 | pubmed:author | pubmed-author:GeorgeThaddeu... | lld:pubmed |
| pubmed-article:17339440 | pubmed:author | pubmed-author:MatsudaJennif... | lld:pubmed |
| pubmed-article:17339440 | pubmed:author | pubmed-author:HagmanJamesJ | lld:pubmed |
| pubmed-article:17339440 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17339440 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17339440 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:17339440 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17339440 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17339440 | pubmed:pagination | 3457-65 | lld:pubmed |
| pubmed-article:17339440 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:meshHeading | pubmed-meshheading:17339440... | lld:pubmed |
| pubmed-article:17339440 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17339440 | pubmed:articleTitle | Temporal dissection of T-bet functions. | lld:pubmed |
| pubmed-article:17339440 | pubmed:affiliation | Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Science Center, 1400 Jackson Street, Denver, CO 80206, USA. | lld:pubmed |
| pubmed-article:17339440 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17339440 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17339440 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:57765 | entrezgene:pubmed | pubmed-article:17339440 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339440 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339440 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339440 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339440 | lld:pubmed |
