| pubmed-article:17321042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17321042 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17321042 | lifeskim:mentions | umls-concept:C0037286 | lld:lifeskim |
| pubmed-article:17321042 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17321042 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17321042 | lifeskim:mentions | umls-concept:C1516463 | lld:lifeskim |
| pubmed-article:17321042 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17321042 | pubmed:dateCreated | 2007-6-11 | lld:pubmed |
| pubmed-article:17321042 | pubmed:abstractText | The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation. | lld:pubmed |
| pubmed-article:17321042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17321042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17321042 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17321042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17321042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17321042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17321042 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17321042 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:DwivediChandr... | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:ZhangXiaoying... | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:FahmyHeshamH | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:KhalifaSherie... | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:ZemanDavidD | lld:pubmed |
| pubmed-article:17321042 | pubmed:author | pubmed-author:KundoorVipraV | lld:pubmed |
| pubmed-article:17321042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17321042 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17321042 | pubmed:volume | 253 | lld:pubmed |
| pubmed-article:17321042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17321042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17321042 | pubmed:pagination | 53-9 | lld:pubmed |
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| pubmed-article:17321042 | pubmed:meshHeading | pubmed-meshheading:17321042... | lld:pubmed |
| pubmed-article:17321042 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17321042 | pubmed:articleTitle | Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice. | lld:pubmed |
| pubmed-article:17321042 | pubmed:affiliation | Department of Pharmaceutical Sciences, 1 Administration Lane, College of Pharmacy, Box 2202C, South Dakota State University, Brookings, SD 57007, USA. | lld:pubmed |
| pubmed-article:17321042 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17321042 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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