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pubmed-article:17315255pubmed:dateCreated2007-4-10lld:pubmed
pubmed-article:17315255pubmed:abstractTextWe demonstrate that solid-state NMR methods can be used to rapidly determine the high-resolution 3D structure of Epothilone B in the polycrystalline state. The solid-state NMR structures exhibit an average heavy atom RMSD to the mean structure of 0.14 A. The 3D-structural analysis leads to stereospecific assignments and provides insight into the influence of intermolecular interactions upon ssNMR chemical-shift parameters. Our results pave the way to the study of ligand-microtubule interactions in a noncrystalline and insoluble environment at atomic level.lld:pubmed
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pubmed-article:17315255pubmed:year2007lld:pubmed
pubmed-article:17315255pubmed:articleTitleHigh-resolution solid-state NMR structure of an anticancer agent.lld:pubmed
pubmed-article:17315255pubmed:affiliationDepartment for NMR-based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.lld:pubmed
pubmed-article:17315255pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17315255pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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