pubmed-article:17291044 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C1328819 | lld:lifeskim |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
pubmed-article:17291044 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
pubmed-article:17291044 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:17291044 | pubmed:dateCreated | 2007-3-23 | lld:pubmed |
pubmed-article:17291044 | pubmed:abstractText | The budding yeast Saccharomyces cerevisiae, a powerful model system for the study of basic eukaryotic cell biology, has been used increasingly as a screening tool for the identification of bioactive small molecules. We have developed a novel yeast toxicity screen that is easily automated and compatible with high-throughput screening robotics. The new screen is quantitative and allows inhibitory potencies to be determined, since the diffusion of the sample provides a concentration gradient and a corresponding toxicity halo. The efficacy of this new screen was illustrated by testing materials including 3104 compounds from the NCI libraries, 167 marine sponge crude extracts, and 149 crude marine-derived fungal extracts. There were 46 active compounds among the NCI set. One very active extract was selected for bioactivity-guided fractionation, resulting in the identification of crambescidin 800 as a potent antifungal agent. | lld:pubmed |
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pubmed-article:17291044 | pubmed:language | eng | lld:pubmed |
pubmed-article:17291044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17291044 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17291044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:17291044 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17291044 | pubmed:month | Mar | lld:pubmed |
pubmed-article:17291044 | pubmed:issn | 0163-3864 | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:DavisRonald... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:CrewsPhillipP | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:HolmanTheodor... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:GiaeverGuriG | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:TenneyKarenK | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:NislowCoreyC | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:LokeyR... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:GassnerNadine... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:St... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:WhiteKimberly... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:BockJonathan... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:TambleCraig... | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:CottonNaomiN | lld:pubmed |
pubmed-article:17291044 | pubmed:author | pubmed-author:ProctorMichae... | lld:pubmed |
pubmed-article:17291044 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17291044 | pubmed:volume | 70 | lld:pubmed |
pubmed-article:17291044 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17291044 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17291044 | pubmed:pagination | 383-90 | lld:pubmed |
pubmed-article:17291044 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
pubmed-article:17291044 | pubmed:meshHeading | pubmed-meshheading:17291044... | lld:pubmed |