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pubmed-article:17289581pubmed:abstractTextExport of mature mRNA to the cytoplasm is the culmination of the nuclear portion of eukaryotic gene expression. After transport-competent mature mRNP export complexes are formed in the nucleus, their passage through nuclear pore complexes (NPCs) is facilitated by the Mex67:Mtr2 heterodimer. At the NPC cytoplasmic face, mRNP remodeling prevents its return to the nucleus and so functions as a molecular ratchet imposing directionality on transport. In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).lld:pubmed
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pubmed-article:17289581pubmed:articleTitleRatcheting mRNA out of the nucleus.lld:pubmed
pubmed-article:17289581pubmed:affiliationMRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK. ms@mrc-lmb.cam.ac.uklld:pubmed
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