| pubmed-article:17273170 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C0596620 | lld:lifeskim |
| pubmed-article:17273170 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:17273170 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17273170 | pubmed:dateCreated | 2007-2-9 | lld:pubmed |
| pubmed-article:17273170 | pubmed:abstractText | Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conversion to lactate, leading to activation of ATP-sensitive potassium channels and to decreased hepatic activity of stearoyl-CoA desaturase-1 (SCD1). SCD1 catalyzed the synthesis of oleyl-CoA from stearoyl-CoA. Curtailing the liver activity of SCD1 was sufficient to lower the hepatic levels of oleyl-CoA and to recapitulate the effects of central glucose administration on VLDL secretion. Notably, portal infusion of oleic acid restored hepatic oleyl-CoA to control levels and negated the effects of both central glucose and SCD1 deficiency on TG-VLDL secretion. These central effects of glucose (but not those of lactate) were rapidly lost in diet-induced obesity. These findings indicate that a defect in brain glucose sensing could play a critical role in the etiology of the metabolic syndrome. | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17273170 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17273170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17273170 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17273170 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:TsoPatrickP | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:RossettiLucia... | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:SchwartzGary... | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:BhanotSanjayS | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:LamTony K TTK | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:PocaiAlessand... | lld:pubmed |
| pubmed-article:17273170 | pubmed:author | pubmed-author:Gutierrez-Jua... | lld:pubmed |
| pubmed-article:17273170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17273170 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:17273170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17273170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17273170 | pubmed:pagination | 171-80 | lld:pubmed |
| pubmed-article:17273170 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17273170 | pubmed:meshHeading | pubmed-meshheading:17273170... | lld:pubmed |
| pubmed-article:17273170 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17273170 | pubmed:articleTitle | Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. | lld:pubmed |
| pubmed-article:17273170 | pubmed:affiliation | Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:17273170 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17273170 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17273170 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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