| pubmed-article:17244316 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C0040018 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C1456868 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17244316 | lifeskim:mentions | umls-concept:C1608705 | lld:lifeskim |
| pubmed-article:17244316 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17244316 | pubmed:dateCreated | 2007-1-24 | lld:pubmed |
| pubmed-article:17244316 | pubmed:abstractText | Thrombin and thrombin peptides play a role in initiating tissue repair. The potential safety and efficacy of TP508 (Chrysalin) treatment of diabetic foot ulcers was evaluated in a 60-subject, prospective, randomized, double-blind, placebo-controlled phase I/II clinical trial. Chrysalin in saline or saline alone was applied topically, twice weekly, to diabetic ulcers with standardized care and offloading. A dose-dependent effect was seen in the per-protocol population where 1 and 10 mug Chrysalin treatment resulted in 45 and 72% more subjects with complete healing than placebo treatment. Chrysalin treatment of foot ulcers more than doubled the incidence of complete healing (p<0.05), increased mean closure rate approximately 80% (p<0.05), and decreased the median time to 100% closure by approximately 40% (p<0.05). Chrysalin treatment of heel ulcers within this population resulted in mean closure rates 165% higher than placebos (p<0.02) and complete healing in 86% (6/7) of ulcers compared with 0% (0/5) of placebo ulcers (p<0.03). Local wound reactions and adverse events (AEs) were equal between groups with no reported drug-related changes in laboratory tests or serious AEs. These results indicate the potential safety and efficacy of Chrysalin for treatment of diabetic foot ulcers. | lld:pubmed |
| pubmed-article:17244316 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17244316 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17244316 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17244316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17244316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17244316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17244316 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17244316 | pubmed:issn | 1067-1927 | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:MaderJon TJT | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:CarneyDarrell... | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:RyabyJames... | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:SatterfieldKa... | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:StoneJefferyJ | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:FifeCarolineC | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:BrillLeonL | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:NorfleetAndre... | lld:pubmed |
| pubmed-article:17244316 | pubmed:author | pubmed-author:ZwernemannAmb... | lld:pubmed |
| pubmed-article:17244316 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17244316 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17244316 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17244316 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17244316 | pubmed:pagination | 23-34 | lld:pubmed |
| pubmed-article:17244316 | pubmed:dateRevised | 2009-8-12 | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:meshHeading | pubmed-meshheading:17244316... | lld:pubmed |
| pubmed-article:17244316 | pubmed:articleTitle | Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study. | lld:pubmed |
| pubmed-article:17244316 | pubmed:affiliation | Department of Anesthesiology, University of Texas Health Science Center, Houston, Texas 77555-0645, USA. | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:17244316 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17244316 | lld:pubmed |
