| pubmed-article:17229101 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0035007 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0026455 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0026456 | lld:lifeskim |
| pubmed-article:17229101 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17229101 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17229101 | pubmed:dateCreated | 2007-1-18 | lld:pubmed |
| pubmed-article:17229101 | pubmed:abstractText | Although nicotine is considered to be responsible for the addictive properties of tobacco, growing evidence underlines the importance of non-nicotine components in smoking reinforcement. It has been shown that tobacco smoke contains monoamine oxidase (MAO) A and B inhibitors and decreases MAO-A and MAO-B activity in smokers. Here, we investigated the effects of clorgyline hydrochloride (irreversible MAO-A inhibitor; 2 mg/kg/day), selegiline (irreversible MAO-B inhibitor; 4 mg/kg) and the beta-carboline norharmane hydrochloride (reversible MAO-B inhibitor; 5 mg/kg/day) treatments on nicotine self-administration (30 microg/kg/infusion, free base) in rats. Independent of the responsiveness to novelty and locomotor activity stimulation, only clorgyline hydrochloride treatment increased the intake of nicotine in a fixed-ratio schedule (FR5) of reinforcement. When a progressive-ratio schedule was implemented, both clorgyline hydrochloride and norharmane hydrochloride treatments potentiated the reinforcing effects of nicotine, whereas selegiline had no effect. Taken together, these results indicate that MAO-A inhibition interacts with nicotine to enhance its rewarding effects in rats and suggest that other compounds present in tobacco, such as beta-carboline, may also play an important role in sustaining smoking behavior in humans. | lld:pubmed |
| pubmed-article:17229101 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17229101 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17229101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229101 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17229101 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17229101 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:KoobGeorge... | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:StinusLuisL | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:ParsonsLoren... | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:CadorMartineM | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:AzarMarc RMR | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:GuillemKarine... | lld:pubmed |
| pubmed-article:17229101 | pubmed:author | pubmed-author:VouillacCarol... | lld:pubmed |
| pubmed-article:17229101 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17229101 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:17229101 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17229101 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17229101 | pubmed:pagination | 3532-40 | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
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| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:meshHeading | pubmed-meshheading:17229101... | lld:pubmed |
| pubmed-article:17229101 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17229101 | pubmed:articleTitle | Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. | lld:pubmed |
| pubmed-article:17229101 | pubmed:affiliation | Laboratoire de Neuropsychobiologie des Désadaptations, UMR CNRS 5541, Université de Bordeaux 2, BP 31, 146 rue Léo Saignat, 33076 Bordeaux, cedex, France. | lld:pubmed |
| pubmed-article:17229101 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17229101 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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