| pubmed-article:17202253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17202253 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:17202253 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17202253 | pubmed:dateCreated | 2007-1-10 | lld:pubmed |
| pubmed-article:17202253 | pubmed:abstractText | We previously described unique features of the IL-15 receptor (IL-15R)alpha. IL-15Ralpha by itself forms stable complexes with IL-15 on cell surfaces and presents IL-15 in trans to neighboring natural killer/T cells. Moreover, the membrane IL-15/IL-15Ralpha complexes (membIL-15) undergo endosomal internalization but survive lysosomal degradation, allowing the complexes to recycle back to the cell surface. Here, we show that membIL-15+ cells act as a persistent source of IL-15 for the surrounding microenvironment (intercellular reservoir effect). Additionally, membIL-15+ cells give rise to augmented retention of IL-15 in the circulation as well as in tissues. Curiously, IL-15 retention was particularly associated with lungs, rather than with lymph nodes, in normal unstimulated mice, which correlated with the preferential homing of antigen-specific CD8 T cells to lungs during their contraction phase in an IL-15Ralpha-dependent manner. Furthermore, membIL-15, unlike soluble IL-15, caused sustained IL-15 signal transduction in the target cells. Collectively, these characteristics define IL-15 as a unique cytokine with prolonged in vivo survival and sustained biological action on the target cells, which may account for the proposed persistent action of IL-15 that helps the long-term survival of functional CD8 memory T cells in vivo. | lld:pubmed |
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| pubmed-article:17202253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17202253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202253 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17202253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17202253 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17202253 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17202253 | pubmed:author | pubmed-author:WaldmannThoma... | lld:pubmed |
| pubmed-article:17202253 | pubmed:author | pubmed-author:SatoNorikoN | lld:pubmed |
| pubmed-article:17202253 | pubmed:author | pubmed-author:TagayaYutakaY | lld:pubmed |
| pubmed-article:17202253 | pubmed:author | pubmed-author:PatelHiral... | lld:pubmed |
| pubmed-article:17202253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17202253 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:17202253 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17202253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17202253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17202253 | pubmed:pagination | 588-93 | lld:pubmed |
| pubmed-article:17202253 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17202253 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17202253 | pubmed:articleTitle | The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. | lld:pubmed |
| pubmed-article:17202253 | pubmed:affiliation | Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:17202253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17202253 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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