| pubmed-article:17194461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17194461 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17194461 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:17194461 | lifeskim:mentions | umls-concept:C0162577 | lld:lifeskim |
| pubmed-article:17194461 | lifeskim:mentions | umls-concept:C0333186 | lld:lifeskim |
| pubmed-article:17194461 | lifeskim:mentions | umls-concept:C2348535 | lld:lifeskim |
| pubmed-article:17194461 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17194461 | pubmed:dateCreated | 2007-10-9 | lld:pubmed |
| pubmed-article:17194461 | pubmed:abstractText | Restenosis after balloon angioplasty and stenting is exacerbated by low flow. Flow-dependent restenosis after angioplasty but not stenting is prevented by the antioxidant pyrrolidine dithiocarbamate (PDTC). c-jun may play a role in these events as AP-1 activity is both flow and redox sensitive. Carotid arteries of cholesterol fed rabbits underwent stenting or balloon injury in the presence of low or normal flow. c-jun mRNA expression was enhanced by low flow and injury (stent>balloon) and inhibited by the antioxidant PDTC irrespective of the injury type. The effect of locally delivered DZ13 (a DNAzyme specific for c-jun) or scrambled DZ13 (inactive DNAzyme) was assessed by histomorphometry at 28 days. Low flow significantly increased intimal hyperplasia in B and S relative to normal flow (P<0.05). The active DNAzyme DZ13 markedly reduced intimal hyperplasia (P<0.001) and increased lumen size (P<0.05) in balloon-injured but not in stented segments, and abrogated the effect of low flow on restenosis after angioplasty, similar to the morphological effects of PDTC. We conclude that c-jun expression is enhanced by low flow and by injury (stent>balloon) and markedly attenuated by PDTC, and that c-jun is an important mediator of flow-dependent restenosis in balloon-injured but not stented vessels. | lld:pubmed |
| pubmed-article:17194461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17194461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17194461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17194461 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17194461 | pubmed:issn | 1879-1484 | lld:pubmed |
| pubmed-article:17194461 | pubmed:author | pubmed-author:WardMichael... | lld:pubmed |
| pubmed-article:17194461 | pubmed:author | pubmed-author:MurrellMelani... | lld:pubmed |
| pubmed-article:17194461 | pubmed:author | pubmed-author:KhachigianLev... | lld:pubmed |
| pubmed-article:17194461 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17194461 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:17194461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17194461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17194461 | pubmed:pagination | 364-71 | lld:pubmed |
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| pubmed-article:17194461 | pubmed:meshHeading | pubmed-meshheading:17194461... | lld:pubmed |
| pubmed-article:17194461 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17194461 | pubmed:articleTitle | The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting. | lld:pubmed |
| pubmed-article:17194461 | pubmed:affiliation | Department of Cardiology, Royal North Shore Hospital, Australia. | lld:pubmed |
| pubmed-article:17194461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17194461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17194461 | lld:pubmed |
