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pubmed-article:17186240pubmed:abstractTextSDX-101 is the non-cyclooxygenase 2-inhibiting R-enantiomer of the non-steroid anti-inflammatory drug etodolac, and has anti-tumour activity in chronic lymphocytic leukaemia (CLL). SDX-308 and SDX-309 are more potent, structurally related indole-pyran analogues of SDX-101. The current study was performed to investigate and quantify the cytotoxic potentiating effects resulting from a combination of either SDX-101, SDX-308 or SDX-309 with standard cytotoxic agents used in the CLL treatment today.lld:pubmed
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pubmed-article:17186240pubmed:articleTitleR-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells.lld:pubmed
pubmed-article:17186240pubmed:affiliationDivision of Clinical Pharmacology, Uppsala University, Uppsala, Sweden. elin.lindhagen@medsci.uu.selld:pubmed
pubmed-article:17186240pubmed:publicationTypeJournal Articlelld:pubmed