| pubmed-article:17164141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0231337 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0033572 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0003692 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C1325410 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C1326057 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
| pubmed-article:17164141 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17164141 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:17164141 | pubmed:dateCreated | 2006-12-13 | lld:pubmed |
| pubmed-article:17164141 | pubmed:abstractText | 15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal human adult prostate and its expression is decreased or lost in high-grade prostate intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal human prostate (NHP) epithelial cells; (2) 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3; (3) 15-LOX2 in NHP cells may be partially involved in cell differentiation; (4) 15-LOX2 is cell-autonomously upregulated in cultured NHP cells and its induction is associated with NHP cell senescence; and (5) 15-LOX2 is a functional prostate tumor suppressor. Here we summarize these new findings to provide a concise view of the potential biological functions of 15-LOX2 in NHP cells and of its deregulation in PCa development. | lld:pubmed |
| pubmed-article:17164141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17164141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17164141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17164141 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17164141 | pubmed:issn | 1098-8823 | lld:pubmed |
| pubmed-article:17164141 | pubmed:author | pubmed-author:TangShaohuaS | lld:pubmed |
| pubmed-article:17164141 | pubmed:author | pubmed-author:BhatiaBobbyB | lld:pubmed |
| pubmed-article:17164141 | pubmed:author | pubmed-author:TangDean GDG | lld:pubmed |
| pubmed-article:17164141 | pubmed:author | pubmed-author:Schneider-Bro... | lld:pubmed |
| pubmed-article:17164141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17164141 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:17164141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17164141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17164141 | pubmed:pagination | 135-46 | lld:pubmed |
| pubmed-article:17164141 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17164141 | pubmed:meshHeading | pubmed-meshheading:17164141... | lld:pubmed |
| pubmed-article:17164141 | pubmed:meshHeading | pubmed-meshheading:17164141... | lld:pubmed |
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| pubmed-article:17164141 | pubmed:meshHeading | pubmed-meshheading:17164141... | lld:pubmed |
| pubmed-article:17164141 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17164141 | pubmed:articleTitle | 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size). | lld:pubmed |
| pubmed-article:17164141 | pubmed:affiliation | Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park-Research Division, 1808 Park Rd. 1C, Smithville, TX 78957, United States. dtang@mdanderson.org | lld:pubmed |
| pubmed-article:17164141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17164141 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17164141 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:17164141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17164141 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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