| pubmed-article:17161853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17161853 | lifeskim:mentions | umls-concept:C0034792 | lld:lifeskim |
| pubmed-article:17161853 | lifeskim:mentions | umls-concept:C0009079 | lld:lifeskim |
| pubmed-article:17161853 | lifeskim:mentions | umls-concept:C0040615 | lld:lifeskim |
| pubmed-article:17161853 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17161853 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17161853 | pubmed:dateCreated | 2007-1-26 | lld:pubmed |
| pubmed-article:17161853 | pubmed:abstractText | The effects of the antipsychotic clozapine on the function of the cloned alpha(7) subunit of the nicotinic acetylcholine (nACh) receptor expressed in Xenopus oocytes was investigated by using the two-electrode voltage-clamp technique. Clozapine reversibly inhibited nicotine (10 microM)-induced currents in a concentration-dependent manner (300 nM to 90 microM), with an IC(50) value of 3.2+/-0.4 microM. The effect of clozapine was not dependent on the membrane potential. Clozapine did not affect the activity of endogenous Ca(2+)-dependent Cl(-) channels since the inhibition by clozapine was unaltered by the intracellularly injected Ca(2+) chelator BAPTA and perfusion with Ca(2+)-free bathing solution containing 2mM Ba(2+). Clozapine decreased the maximal nicotine-induced responses without significantly affecting its potency, indicating that it acts as a noncompetitive antagonist on alpha(7)-nACh receptors. In hippocampal slices, the whole-cell recordings from CA1 pyramidal neurons indicated that the increases in the frequency and amplitudes of the GABA-mediated spontaneous inhibitory postsynaptic currents induced by bath application of 2 mM choline, a specific agonist for alpha(7)-nACh receptors, were abolished after 10 min application of 5 microM clozapine. In conclusion, these results demonstrate that clozapine inhibits the function of alpha(7)-nACh receptors expressed in Xenopus oocytes and in hippocampal neurons. | lld:pubmed |
| pubmed-article:17161853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17161853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17161853 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17161853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17161853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17161853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17161853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17161853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17161853 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17161853 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:17161853 | pubmed:author | pubmed-author:ZhangLiL | lld:pubmed |
| pubmed-article:17161853 | pubmed:author | pubmed-author:OzMuratM | lld:pubmed |
| pubmed-article:17161853 | pubmed:author | pubmed-author:MoralesMarise... | lld:pubmed |
| pubmed-article:17161853 | pubmed:author | pubmed-author:SinghalSachin... | lld:pubmed |
| pubmed-article:17161853 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17161853 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:17161853 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17161853 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17161853 | pubmed:pagination | 387-94 | lld:pubmed |
| pubmed-article:17161853 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
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| pubmed-article:17161853 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17161853 | pubmed:articleTitle | Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors. | lld:pubmed |
| pubmed-article:17161853 | pubmed:affiliation | Laboratory of Molecular & Cellular Neurobiology, National Institute on Alcohol Abuse & Alcoholism, NIH/DHHS, 12501 Washington Avenue, Bethesda, MD 20892-8205, USA. | lld:pubmed |
| pubmed-article:17161853 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17161853 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17161853 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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