| pubmed-article:17141155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0015687 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0753137 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:17141155 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:17141155 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17141155 | pubmed:dateCreated | 2006-12-4 | lld:pubmed |
| pubmed-article:17141155 | pubmed:abstractText | The secretion and extracellular transport of Wnt protein are thought to be well-regulated processes. Wnt is known to be acylated with palmitic acid at a conserved cysteine residue (Cys77 in murine Wnt-3a), and this residue appears to be required for the control of extracellular transport. Here, we show that murine Wnt-3a is also acylated at a conserved serine residue (Ser209). Of note, we demonstrated that this residue is modified with a monounsaturated fatty acid, palmitoleic acid. Wnt-3a defective in acylation at Ser209 is not secreted from cells in culture or in Xenopus embryos, but it is retained in the endoplasmic reticulum (ER). Furthermore, Porcupine, a protein with structural similarities to membrane-bound O-acyltransferases, is required for Ser209-dependent acylation, as well as for Wnt-3a transport from the ER for secretion. These results strongly suggest that Wnt protein requires a particular lipid modification for proper intracellular transport during the secretory process. | lld:pubmed |
| pubmed-article:17141155 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17141155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17141155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17141155 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17141155 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:TakadaRitsuko... | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:TakadaShinjiS | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:UenoNaotoN | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:NoriokaShigem... | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:KondohHisatoH | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:TakaoToshifum... | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:SatomiYoshino... | lld:pubmed |
| pubmed-article:17141155 | pubmed:author | pubmed-author:KurataTomokoT | lld:pubmed |
| pubmed-article:17141155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17141155 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:17141155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17141155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17141155 | pubmed:pagination | 791-801 | lld:pubmed |
| pubmed-article:17141155 | pubmed:dateRevised | 2007-9-21 | lld:pubmed |
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| pubmed-article:17141155 | pubmed:meshHeading | pubmed-meshheading:17141155... | lld:pubmed |
| pubmed-article:17141155 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17141155 | pubmed:articleTitle | Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. | lld:pubmed |
| pubmed-article:17141155 | pubmed:affiliation | Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan. | lld:pubmed |
| pubmed-article:17141155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17141155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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