| pubmed-article:17138816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0035078 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C1176309 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0035363 | lld:lifeskim |
| pubmed-article:17138816 | lifeskim:mentions | umls-concept:C0205179 | lld:lifeskim |
| pubmed-article:17138816 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17138816 | pubmed:dateCreated | 2007-3-7 | lld:pubmed |
| pubmed-article:17138816 | pubmed:abstractText | Patients with multiple myeloma (MM) frequently present with concomitant renal dysfunction, and those requiring dialysis have particularly poor outcomes. Bortezomib is a reversible proteasome inhibitor with significant activity in MM. This retrospective case analysis evaluated the feasibility and activity of bortezomib-based therapy in MM patients (n = 24) requiring dialysis support for advanced renal failure. All but 1 patient were undergoing dialysis at the time of therapy. Patients received bortezomib alone or bortezomib-based combination therapy. Among 20 patients with available response data, overall response rate (complete response [CR] + partial response) was 75%, with 30% CR + near CR. One patient was spared dialysis, and 3 other patients became independent of dialysis following bortezomib-based treatment. These encouraging results suggest that bortezomib or bortezomib-based regimens can be used in MM patients requiring dialysis, with manageable toxicities. Further studies will more formally evaluate the impact of bortezomib-based regimens in this patient population. | lld:pubmed |
| pubmed-article:17138816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17138816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17138816 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17138816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17138816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17138816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17138816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17138816 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17138816 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:MehtaJayeshJ | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:SinghalSeemaS | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:LonialSagarS | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:MunshiNikhil... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:RichardsonPau... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:MillerKena... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:SchlossmanRob... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:KaufmanJonath... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:TarimanJoseph... | lld:pubmed |
| pubmed-article:17138816 | pubmed:author | pubmed-author:Chanan-KhanAs... | lld:pubmed |
| pubmed-article:17138816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17138816 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17138816 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:17138816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17138816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17138816 | pubmed:pagination | 2604-6 | lld:pubmed |
| pubmed-article:17138816 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
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| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:meshHeading | pubmed-meshheading:17138816... | lld:pubmed |
| pubmed-article:17138816 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17138816 | pubmed:articleTitle | Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study. | lld:pubmed |
| pubmed-article:17138816 | pubmed:affiliation | Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA. asher.chanan-khan@roswellpark.org | lld:pubmed |
| pubmed-article:17138816 | pubmed:publicationType | Journal Article | lld:pubmed |
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