| pubmed-article:1713565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C0019189 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C2697585 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1713565 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1713565 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1713565 | pubmed:dateCreated | 1991-8-30 | lld:pubmed |
| pubmed-article:1713565 | pubmed:abstractText | T lymphocyte-mediated cytolytic immune reactions are considered a major cause of hepatocyte injury in chronic viral and autoimmune hepatitis. To further investigate local immune responses, we studied the expression of lymphocyte antigens and cell-cell interaction molecules known to be involved in effector-target cell interactions by light and electron microscopy in liver biopsy specimens from patients with chronic viral and autoimmune hepatitis. CD8+ lymphocytes were found to be the predominant population of cells in the inflammatory infiltrate in chronic hepatitis B and non-A, non-B hepatitis. In contrast, CD4+ cells constituted a comparably higher proportion of cells and were more numerous than CD8+ cells in chronic autoimmune hepatitis. In both viral and autoimmune hepatitis, a substantial portion of lymphocytes expressed activation antigens such as T11/3 (CD2R) and IL-2-R (CD25). Lymphocyte function-associated antigen-3 (CD58), which mediates lymphocyte adhesion and activation and is the natural ligand of the CD2/T11 lymphocyte surface receptor, could be demonstrated on endothelial cells and hepatocytes. Hepatocellular lymphocyte function-associated antigen-3 expression in chronic hepatitis showed membranous and cytoplasmic staining of hepatocytes and had a positive correlation with the degree of inflammatory activity. These results suggest that effector-target interactions between hepatocytes and lymphocytes mediated by the lymphocyte function-associated antigen-3/CD2 pathway play a role in chronic inflammatory liver disease. Possible functional consequences of this interaction include enhancement of antigen-specific immune reactions and antigen-independent mechanisms of T cell activation, which may contribute considerably to the degree of inflammatory activity and tissue damage in chronic hepatitis. | lld:pubmed |
| pubmed-article:1713565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1713565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1713565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1713565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1713565 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1713565 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:ThoenenHH | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:Meyer zum... | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:HessGG | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:DienesH PHP | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:MannsMM | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:MeuerS CSC | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:MoebiusUU | lld:pubmed |
| pubmed-article:1713565 | pubmed:author | pubmed-author:AutschbachFF | lld:pubmed |
| pubmed-article:1713565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1713565 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:1713565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1713565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1713565 | pubmed:pagination | 223-30 | lld:pubmed |
| pubmed-article:1713565 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:meshHeading | pubmed-meshheading:1713565-... | lld:pubmed |
| pubmed-article:1713565 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1713565 | pubmed:articleTitle | Hepatocellular expression of lymphocyte function-associated antigen 3 in chronic hepatitis. | lld:pubmed |
| pubmed-article:1713565 | pubmed:affiliation | Institut für Pathologie, Johannes Gutenberg Universität, Mainz, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:1713565 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1713565 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1713565 | lld:pubmed |
