| pubmed-article:17124500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17124500 | lifeskim:mentions | umls-concept:C1159978 | lld:lifeskim |
| pubmed-article:17124500 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:17124500 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:17124500 | lifeskim:mentions | umls-concept:C0074992 | lld:lifeskim |
| pubmed-article:17124500 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17124500 | pubmed:dateCreated | 2006-12-13 | lld:pubmed |
| pubmed-article:17124500 | pubmed:abstractText | Sphingosine 1-phosphate (S1P), produced by sphingosine kinase (SPHK), acts both by intracellular and extracellular modes. We evaluated the role of SPHK1 and S1P in osteoclastogenesis using bone marrow-derived macrophage (BMM) single and BMM/osteoblast coculture systems. In BMM single cultures, the osteoclastogenic factor receptor activator of NF-kappaB ligand (RANKL) upregulated SPHK1 and increased S1P production and secretion. SPHK1 siRNA enhanced and SPHK1 overexpression attenuated osteoclastogenesis via modulation of p38 and ERK activities, and NFATc1 and c-Fos levels. Extracellular S1P had no effect in these cultures. These data suggest that intracellular S1P produced in response to RANKL forms a negative feedback loop in BMM single cultures. In contrast, S1P addition to BMM/osteoblast cocultures greatly increased osteoclastogenesis by increasing RANKL in osteoblasts via cyclooxygenase-2 and PGE(2) regulation. S1P also stimulated osteoblast migration and survival. The RANKL elevation and chemotactic effects were also observed with T cells. These results indicate that secreted S1P attracts and acts on osteoblasts and T cells to augment osteoclastogenesis. Taken together, S1P plays an important role in osteoclastogenesis regulation and in communication between osteoclasts and osteoblasts or T cells. | lld:pubmed |
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| pubmed-article:17124500 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17124500 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17124500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17124500 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17124500 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:KimHong-HeeHH | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:BannoYoshikoY | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:HuangHaoH | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:RyuJiyoonJ | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:ChangEun-JuEJ | lld:pubmed |
| pubmed-article:17124500 | pubmed:author | pubmed-author:KimHyung... | lld:pubmed |
| pubmed-article:17124500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17124500 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:17124500 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17124500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17124500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17124500 | pubmed:pagination | 5840-51 | lld:pubmed |
| pubmed-article:17124500 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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