| pubmed-article:17113580 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17113580 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:17113580 | lifeskim:mentions | umls-concept:C1456398 | lld:lifeskim |
| pubmed-article:17113580 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17113580 | pubmed:issue | 28-29 | lld:pubmed |
| pubmed-article:17113580 | pubmed:dateCreated | 2006-12-4 | lld:pubmed |
| pubmed-article:17113580 | pubmed:abstractText | Mitochondrial thioredoxin (mtTrx) can be oxidized in response to inducers of oxidative stress; yet the functional consequences of the oxidation have not been determined. This study evaluated the redox status of mtTrx and its association to oxidant-induced apoptosis. Results showed that mtTrx was oxidized after exposure to peroxides and diamide. Overexpression of mtTrx protected against diamide-induced oxidation and cytotoxicity. Oxidation of mtTrx was also achieved by knocking down its reductase; and lead to increased susceptibility to cell death. The data indicate that the redox status of mtTrx is a regulatory mechanism underlying the vulnerability of mitochondria to oxidative injury. | lld:pubmed |
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| pubmed-article:17113580 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17113580 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17113580 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17113580 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17113580 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17113580 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:17113580 | pubmed:author | pubmed-author:DaleT JTJ | lld:pubmed |
| pubmed-article:17113580 | pubmed:author | pubmed-author:JonesDean PDP | lld:pubmed |
| pubmed-article:17113580 | pubmed:author | pubmed-author:CaiJiyangJ | lld:pubmed |
| pubmed-article:17113580 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17113580 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17113580 | pubmed:volume | 580 | lld:pubmed |
| pubmed-article:17113580 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17113580 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17113580 | pubmed:pagination | 6596-602 | lld:pubmed |
| pubmed-article:17113580 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
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| pubmed-article:17113580 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17113580 | pubmed:articleTitle | Mitochondrial thioredoxin in regulation of oxidant-induced cell death. | lld:pubmed |
| pubmed-article:17113580 | pubmed:affiliation | Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. | lld:pubmed |
| pubmed-article:17113580 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17113580 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17113580 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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