| pubmed-article:1711082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C1446680 | lld:lifeskim |
| pubmed-article:1711082 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1711082 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1711082 | pubmed:dateCreated | 1991-7-23 | lld:pubmed |
| pubmed-article:1711082 | pubmed:abstractText | We have generated a number of mAb against various epitopes on the external envelope glycoprotein, gp46, of human T cell leukemia virus type I (HTLV-I) from a WKA rat immunized with a recombinant vaccinia virus containing the HTLV-I env gene. Among these mAb, one group of mAb, represented by a mAb designated LAT-27, could neutralize the infectivity of HTLV-I, as determined by a HTLV-I-mediated cell fusion inhibition assay. LAT-27 also interfered with transformation of normal T lymphocytes by HTLV-I in vitro. An antibody-binding assay using overlapping synthetic oligopeptides showed that LAT-27 bound specifically to 10-mer peptides that contained the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu). Antibodies from HTLV-I+ humans interfered with the binding of LAT-27 to gp46 Ag. Sera from rabbits immunized with a LAT-27-reactive peptide, 190-199, conjugated with OVA, but not sera from OVA-immunized rabbits, reacted with gp46 Ag and neutralized infectivity of HTLV-I. These results show that the HTLV-I neutralization epitope recognized by LAT-27 locates to the gp46 amino acids 191-196, and that immunization with a peptide containing the LAT-27 epitope can elicit an HTLV-I neutralizing antibody response. | lld:pubmed |
| pubmed-article:1711082 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1711082 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1711082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1711082 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1711082 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1711082 | pubmed:author | pubmed-author:TanakaYY | lld:pubmed |
| pubmed-article:1711082 | pubmed:author | pubmed-author:ShirakiHH | lld:pubmed |
| pubmed-article:1711082 | pubmed:author | pubmed-author:ShidaHH | lld:pubmed |
| pubmed-article:1711082 | pubmed:author | pubmed-author:TozawaHH | lld:pubmed |
| pubmed-article:1711082 | pubmed:author | pubmed-author:ZengLL | lld:pubmed |
| pubmed-article:1711082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1711082 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1711082 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1711082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1711082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1711082 | pubmed:pagination | 354-60 | lld:pubmed |
| pubmed-article:1711082 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1711082 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1711082 | pubmed:articleTitle | Identification of a neutralization epitope on the envelope gp46 antigen of human T cell leukemia virus type I and induction of neutralizing antibody by peptide immunization. | lld:pubmed |
| pubmed-article:1711082 | pubmed:affiliation | Department of Immunology, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan. | lld:pubmed |
| pubmed-article:1711082 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1711082 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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