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pubmed-article:17078094pubmed:abstractTextPantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disorder with onset in childhood and rapid progression. There is no causative and insufficient symptomatic drug therapy. Deep brain stimulation (DBS) of the internal pallidum (GPi) has been reported to improve motor function. Most case reports, however, are limited to short observational periods. The impact of DBS on the progression and life expectancy in PKAN is unknown. We present a 5-year outcome and video documentation of bilateral GPi-DBS of an adolescent patient suffering from genetically defined PKAN.lld:pubmed
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pubmed-article:17078094pubmed:authorpubmed-author:KrauseMartinMlld:pubmed
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pubmed-article:17078094pubmed:copyrightInfoCopyright 2006 Movement Disorder Society.lld:pubmed
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pubmed-article:17078094pubmed:articleTitleLong-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration.lld:pubmed
pubmed-article:17078094pubmed:affiliationDepartment of Neurology, Ruprecht-Krals-University, INF 400, Heidelberg, Germany. martin_krause@med.uni-hedelberg.delld:pubmed
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