| pubmed-article:1706603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1706603 | lifeskim:mentions | umls-concept:C1417807 | lld:lifeskim |
| pubmed-article:1706603 | pubmed:issue | 1 Pt 1 | lld:pubmed |
| pubmed-article:1706603 | pubmed:dateCreated | 1991-4-30 | lld:pubmed |
| pubmed-article:1706603 | pubmed:abstractText | To elucidate the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in hypertension, we investigated the biosynthesis and secretion of ANP in deoxycorticosterone acetate (DOCA)-salt hypertensive rats and also examined the effect of passive immunization with monoclonal antibody raised against alpha-rat ANP on the development of hypertension in DOCA-salt rats. The plasma ANP level in DOCA-salt rats was significantly elevated in comparison to control rats. While the atrial ANP concentration in DOCA-salt rats was not significantly altered, the atrial level of ANPmRNA in DOCA-salt rats was two-fold higher than that in control rats. These results suggest the augmented biosynthesis of ANP in the atrium and the oversecretion of ANP from the heart in DOCA-salt rats. The levels of ANP and ANPmRNA in the ventricle of DOCA-salt rats exhibited significant increases, compared with those in control rats, suggesting the induction of ANP gene expression in the ventricle of DOCA-salt hypertensive rats under pre/after overload. Weekly intravenous administrations of monoclonal antibody with high affinity for alpha-rat ANP significantly augmented the rise in blood pressure of DOCA-salt rats. These results support the hypothesis that the augmented secretion of ANP is one of the defensive mechanisms to counteract high arterial pressure in this model of hypertension. | lld:pubmed |
| pubmed-article:1706603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1706603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1706603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1706603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1706603 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1706603 | pubmed:issn | 0895-7061 | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:YamadaTT | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:SaitoYY | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:NakaiMM | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:ItohHH | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:HosodaKK | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:AraiHH | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:MukoyamaMM | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:SugaSS | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:ShirakamiGG | lld:pubmed |
| pubmed-article:1706603 | pubmed:author | pubmed-author:ShionoSS | lld:pubmed |
| pubmed-article:1706603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1706603 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:1706603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1706603 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1706603 | pubmed:pagination | 39-44 | lld:pubmed |
| pubmed-article:1706603 | pubmed:dateRevised | 2009-2-24 | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
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| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:meshHeading | pubmed-meshheading:1706603-... | lld:pubmed |
| pubmed-article:1706603 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1706603 | pubmed:articleTitle | Pathophysiological role of augmented atrial natriuretic polypeptide gene expression in DOCA-salt hypertension. Effects of atrial natriuretic polypeptide monoclonal antibody. | lld:pubmed |
| pubmed-article:1706603 | pubmed:affiliation | Department of Medicine, Kyoto University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:1706603 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1706603 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1706603 | lld:pubmed |
