| pubmed-article:17065558 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0042567 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0007590 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C1156189 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C1456459 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:17065558 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:17065558 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17065558 | pubmed:dateCreated | 2006-12-28 | lld:pubmed |
| pubmed-article:17065558 | pubmed:abstractText | Chromatin assembly factor-1 (CAF-1), a complex consisting of p150, p60, and p48 subunits, is highly conserved from yeast to humans and facilitates nucleosome assembly of newly replicated DNA in vitro. To investigate roles of CAF-1 in vertebrates, we generated two conditional DT40 mutants, respectively, devoid of CAF-1p150 and p60. Depletion of each of these CAF-1 subunits led to delayed S-phase progression concomitant with slow DNA synthesis, followed by accumulation in late S/G2 phase and aberrant mitosis associated with extra centrosomes, and then the final consequence was cell death. We demonstrated that CAF-1 is necessary for rapid nucleosome formation during DNA replication in vivo as well as in vitro. Loss of CAF-1 was not associated with the apparent induction of phosphorylations of S-checkpoint kinases Chk1 and Chk2. To elucidate the precise role of domain(s) in CAF-1p150, functional dissection analyses including rescue assays were preformed. Results showed that the binding abilities of CAF-1p150 with CAF-1p60 and DNA polymerase sliding clamp proliferating cell nuclear antigen (PCNA) but not with heterochromatin protein HP1-gamma are required for cell viability. These observations highlighted the essential role of CAF-1-dependent nucleosome assembly in DNA replication and cell proliferation through its interaction with PCNA. | lld:pubmed |
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| pubmed-article:17065558 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17065558 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065558 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17065558 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17065558 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17065558 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:17065558 | pubmed:author | pubmed-author:FukagawaTatsu... | lld:pubmed |
| pubmed-article:17065558 | pubmed:author | pubmed-author:NakayamaTatsu... | lld:pubmed |
| pubmed-article:17065558 | pubmed:author | pubmed-author:TakamiYasunar... | lld:pubmed |
| pubmed-article:17065558 | pubmed:author | pubmed-author:OnoTatsuyaT | lld:pubmed |
| pubmed-article:17065558 | pubmed:author | pubmed-author:ShibaharaKei-... | lld:pubmed |
| pubmed-article:17065558 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17065558 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:17065558 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17065558 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17065558 | pubmed:pagination | 129-41 | lld:pubmed |
| pubmed-article:17065558 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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