| pubmed-article:17064081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:17064081 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:17064081 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17064081 | pubmed:dateCreated | 2006-10-26 | lld:pubmed |
| pubmed-article:17064081 | pubmed:abstractText | Tropane-based photoaffinity ligands covalently bind to discrete points of attachment on the dopamine transporter (DAT). To further explore structure-activity relations, a ligand in which the photoactivated group was extended from the 3-position of the tropane ring was synthesized from cocaine via a Stille or Suzuki coupling strategy. 3-(4'-Azido-3'-iodo-biphenyl-4-yl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (11; K(i) = 15.1 +/- 2.2 nM) demonstrated high binding affinity for the DAT. Moreover, this compound showed moderate binding affinity for the serotonin transporter (SERT, K(i) = 109 +/- 14 nM), suggesting the potential utility of [(125)I]11 in both DAT and SERT protein structure studies. | lld:pubmed |
| pubmed-article:17064081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17064081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17064081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17064081 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17064081 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:KatzJonathan... | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:KopajticThere... | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:NewmanAmy... | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:ChaJoo HwanJH | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:CaoJianjingJ | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:LeverJohn RJR | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:ParnasM... | lld:pubmed |
| pubmed-article:17064081 | pubmed:author | pubmed-author:VaughanRoxann... | lld:pubmed |
| pubmed-article:17064081 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17064081 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:17064081 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:17064081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17064081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17064081 | pubmed:pagination | 6621-5 | lld:pubmed |
| pubmed-article:17064081 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:meshHeading | pubmed-meshheading:17064081... | lld:pubmed |
| pubmed-article:17064081 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17064081 | pubmed:articleTitle | Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. | lld:pubmed |
| pubmed-article:17064081 | pubmed:affiliation | Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health/DHHS, Baltimore, MD, USA. anewman@intra.nida.nih.gov | lld:pubmed |
| pubmed-article:17064081 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17064081 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17064081 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17064081 | lld:pubmed |
