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pubmed-article:17062679pubmed:abstractTextHepatoma-derived growth factor (HDGF) is a nucleus-targeted growth factor playing an important role in the development and progression of cancers. This study investigated the correlation of HDGF expression and prognosis in patients with pancreatic ductal carcinoma. Patients and Methods: HDGF expression in pancreatic cancer cell lines was analyzed by Western blotting. HDGF expression was analyzed by immunohistochemistry for 50 patients with primary ductal carcinoma of the pancreas (33 male and 17 female) ranging in age from 48 to 80 years (median, 65 years) receiving surgical treatment. Cancer cells showing stronger staining than the noncancerous ducts were regarded as positive. Cases showing positive staining in < 90% and > 90% of tumor cells were regarded as HDGF labeling index (LI) levels 1 and 2, respectively. HDGF LI was determined separately for the nucleus and the cytoplasm.lld:pubmed
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pubmed-article:17062679pubmed:articleTitleHepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer.lld:pubmed
pubmed-article:17062679pubmed:affiliationDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Osaka, Japan.lld:pubmed
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