| pubmed-article:17053834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17053834 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17053834 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17053834 | pubmed:dateCreated | 2006-11-2 | lld:pubmed |
| pubmed-article:17053834 | pubmed:abstractText | Cylindromatosis (CYLD) is a deubiquitinating enzyme that is altered in patients with familial cylindromatosis, a condition characterized by numerous benign adnexal tumors. However, the regulatory function of CYLD remains unsettled. Here we show that the development of B cells, T cells, and myeloid cells was unaffected in CYLD-deficient mice, but that the activation of these cells with mediators of innate and adaptive immunity resulted in enhanced NF-kappaB and JNK activity associated with increased TNF receptor-associated factor 2 (TRAF2) and NF-kappaB essential modulator (NEMO) ubiquitination. CYLD-deficient mice were more susceptible to induced colonic inflammation and showed a dramatic increase in the incidence of tumors compared with controls in a colitis-associated cancer model. These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo. | lld:pubmed |
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| pubmed-article:17053834 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17053834 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17053834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17053834 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17053834 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:FussIvan JIJ | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:ZhangJunJ | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:JainAshishA | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:MaChi ACA | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:DerryJonathan... | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:TemmermanStep... | lld:pubmed |
| pubmed-article:17053834 | pubmed:author | pubmed-author:StirlingBrigi... | lld:pubmed |
| pubmed-article:17053834 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17053834 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:17053834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17053834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17053834 | pubmed:pagination | 3042-9 | lld:pubmed |
| pubmed-article:17053834 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17053834 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17053834 | pubmed:articleTitle | Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. | lld:pubmed |
| pubmed-article:17053834 | pubmed:affiliation | Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:17053834 | pubmed:publicationType | Journal Article | lld:pubmed |
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