| pubmed-article:17052689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0289313 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0536847 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17052689 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17052689 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17052689 | pubmed:dateCreated | 2006-10-31 | lld:pubmed |
| pubmed-article:17052689 | pubmed:abstractText | We investigate the effect of rosiglitazone, a ligand for peroxisome proliferator-activated receptor-gamma (PPARgamma) with anti-inflammatory and anti-oxidative actions, on hippocampal injury and its roles in mitochondrial uncoupling protein 2 (UCP2) expression caused by transient global ischemia (TGI) in rats. Increased UCP2 expression was observed in mitochondria of hippocampal CA1 2-24h after TGI/reperfusion, with maximal expression levels at 6-18h. Administration of rosiglitazone to hippocampus 30min prior to the onset of TGI further enhanced mitochondrial UCP2 expression 2-6h following TGI/reperfusion. Rats subjected to TGI/reperfusion displayed a significant increase in lipid peroxidation, based on increased malondialdehyde (MDA) levels, in hippocampal CA1 mitochondria 2-6 h after reperfusion. Rosiglitazone significantly attenuated TGI/reperfusion-induced lipid peroxidation and suppressed hippocampal CA1 neuronal death based on the surviving neuronal counts. In conclusion, our results provide correlative evidence for the "PPARgamma-->UCP2-->neuroprotection" cascade in ischemic brain injury. | lld:pubmed |
| pubmed-article:17052689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17052689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052689 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17052689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17052689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17052689 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17052689 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:LiouChia-WeiC... | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:LinTsu-KungTK | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:YangDing-IDI | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:ShawFu-ZenFZ | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:ChenShang-Der... | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:ChuangYao-Chu... | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:WuHsin-YiHY | lld:pubmed |
| pubmed-article:17052689 | pubmed:author | pubmed-author:LeeSu-YingSY | lld:pubmed |
| pubmed-article:17052689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17052689 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17052689 | pubmed:volume | 351 | lld:pubmed |
| pubmed-article:17052689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17052689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17052689 | pubmed:pagination | 198-203 | lld:pubmed |
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| pubmed-article:17052689 | pubmed:meshHeading | pubmed-meshheading:17052689... | lld:pubmed |
| pubmed-article:17052689 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17052689 | pubmed:articleTitle | Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2. | lld:pubmed |
| pubmed-article:17052689 | pubmed:affiliation | Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan. | lld:pubmed |
| pubmed-article:17052689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17052689 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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