| pubmed-article:17049851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C1142985 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C1260969 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:17049851 | lifeskim:mentions | umls-concept:C0598973 | lld:lifeskim |
| pubmed-article:17049851 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17049851 | pubmed:dateCreated | 2006-12-25 | lld:pubmed |
| pubmed-article:17049851 | pubmed:abstractText | The underlying principle of drug design in this paper is that the maximum retention of the functional groups that exist in the marketed drug would provide a higher probability for comparable safety while the conformational changes in the newly created analogs should not constitute a significant structural variation to adversely affect biological activity. Four individual isomers of backbone re-organized ezetimibe analogs were designed and synthesized. Their effects on the cholesterol levels in rat serum were evaluated by a high-cholesterol and high-fat diet feeding experiment. All the new analogs showed significant effect in lowering the levels of total cholesterol in serum. | lld:pubmed |
| pubmed-article:17049851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17049851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17049851 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17049851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17049851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17049851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17049851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17049851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17049851 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17049851 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:17049851 | pubmed:author | pubmed-author:DeebZ EZE | lld:pubmed |
| pubmed-article:17049851 | pubmed:author | pubmed-author:BaiXuX | lld:pubmed |
| pubmed-article:17049851 | pubmed:author | pubmed-author:FuRenzhongR | lld:pubmed |
| pubmed-article:17049851 | pubmed:author | pubmed-author:XuXianxiuX | lld:pubmed |
| pubmed-article:17049851 | pubmed:author | pubmed-author:ChenShengwuS | lld:pubmed |
| pubmed-article:17049851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17049851 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17049851 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17049851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17049851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17049851 | pubmed:pagination | 101-4 | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:meshHeading | pubmed-meshheading:17049851... | lld:pubmed |
| pubmed-article:17049851 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17049851 | pubmed:articleTitle | Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions. | lld:pubmed |
| pubmed-article:17049851 | pubmed:affiliation | The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, 75 Haiwai Street, Changchun, Jilin 130012, PR China. | lld:pubmed |
| pubmed-article:17049851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17049851 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17049851 | lld:chembl |
