| pubmed-article:1704005 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C0030016 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C0814810 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1704005 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:1704005 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1704005 | pubmed:dateCreated | 1991-3-11 | lld:pubmed |
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| pubmed-article:1704005 | pubmed:abstractText | In Escherichia coli K-12, expression of zwf, the gene for glucose 6-phosphate dehydrogenase, is coordinated with the cellular growth rate and induced by superoxide-generating agents. To initiate the study of the molecular mechanisms regulating its expression, the gene was cloned and its DNA sequence was determined. The 5' ends of zwf mRNA isolated from cells growing in glucose and acetate minimal media were mapped. The map was complex in that transcripts mapped to -45, -52, and -62, with respect to the beginning of the coding sequence. Three analytical methods were used to search the DNA sequence for putative promoters. Only one sequence for a promoter recognized by the sigma 70 form of RNA polymerase was found by all three search routines that could be aligned with a mapped transcript, indicating that the other transcripts arise by processing of the mRNA. A computer-assisted search did not reveal a thermodynamically stable long-range mRNA secondary structure that is capable of sequestering the translation initiation region, which suggests that growth-rate-dependent regulation of glucose 6-phosphate dehydrogenase level may not be carried out by a mechanism similar to the one for the gene (gnd) for 6-phosphogluconate dehydrogenase. The DNA segment between the -10 hexamer and the start point of transcription resembles the discriminator sequence of stable RNA genes, which has been implicated in stringent control and growth-rate-dependent regulation. | lld:pubmed |
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| pubmed-article:1704005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1704005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1704005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1704005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1704005 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1704005 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:1704005 | pubmed:author | pubmed-author:WolfR EREJr | lld:pubmed |
| pubmed-article:1704005 | pubmed:author | pubmed-author:RowleyD LDL | lld:pubmed |
| pubmed-article:1704005 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1704005 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:1704005 | pubmed:geneSymbol | zwf | lld:pubmed |
| pubmed-article:1704005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1704005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1704005 | pubmed:pagination | 968-77 | lld:pubmed |
| pubmed-article:1704005 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1704005 | pubmed:meshHeading | pubmed-meshheading:1704005-... | lld:pubmed |
