| pubmed-article:17011606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17011606 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17011606 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:17011606 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:17011606 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17011606 | pubmed:dateCreated | 2006-11-20 | lld:pubmed |
| pubmed-article:17011606 | pubmed:abstractText | The purpose of this study was to examine the distribution of brevetoxin-3 administered to pregnant dams and to determine the extent of placental transport to fetuses. Twenty-nine pregnant CD-1 mice were administered (3)H-brevetoxin-3 ( approximately 1.3 microCi/animal; approximately 2.8 microg compound/kg) by intratracheal instillation on one of gestational days 15-18. Groups of four or five dams were killed at selected times through 48 h post-dosing. Four pregnant dams were administered (3)H-brevetoxin-3 on gestational day 15 or 16 via osmotic minipump to provide continuous delivery of compound ( approximately 0.13 microCi, 7.5 ng compound/day) over a 72-h period. Then the dams and fetuses were killed. Brevetoxin-associated radioactivity was detected in placentas and fetuses within 0.5h of intratracheal administration. Concentrations of brevetoxin equivalents in fetuses were approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses was 0.1 ng/g, lower than that present in most maternal tissues. Results demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure and repeated low-dose exposure. The consequences of these findings for pregnant women exposed to brevetoxins by inhalation or ingestion remain to be determined. | lld:pubmed |
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| pubmed-article:17011606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17011606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17011606 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17011606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17011606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17011606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17011606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17011606 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17011606 | pubmed:issn | 0041-0101 | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:BadenDaniel... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:FlemingLora... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:BensonJanet... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:TibbettsBrad... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:BackerLorrain... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:GomezAndrea... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:StatomGloria... | lld:pubmed |
| pubmed-article:17011606 | pubmed:author | pubmed-author:ReichAndrewA | lld:pubmed |
| pubmed-article:17011606 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17011606 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17011606 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:17011606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17011606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17011606 | pubmed:pagination | 1018-26 | lld:pubmed |
| pubmed-article:17011606 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
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| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:meshHeading | pubmed-meshheading:17011606... | lld:pubmed |
| pubmed-article:17011606 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17011606 | pubmed:articleTitle | Placental transport of brevetoxin-3 in CD-1 mice. | lld:pubmed |
| pubmed-article:17011606 | pubmed:affiliation | Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE., Albuquerque NM 87108, USA. jbenson@LRRI.org | lld:pubmed |
| pubmed-article:17011606 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17011606 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17011606 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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