| pubmed-article:17009877 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17009877 | lifeskim:mentions | umls-concept:C1521980 | lld:lifeskim |
| pubmed-article:17009877 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:17009877 | lifeskim:mentions | umls-concept:C1415408 | lld:lifeskim |
| pubmed-article:17009877 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17009877 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17009877 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17009877 | pubmed:dateCreated | 2006-11-29 | lld:pubmed |
| pubmed-article:17009877 | pubmed:abstractText | The histone variant H2A.Z is evolutionarily conserved and plays an essential role in mice, Drosophila, and Tetrahymena. The essential function of H2A.Z is unknown, with some studies suggesting a role in transcriptional repression and others in activation. Here we show that Caenorhabditis elegans HTZ-1/H2A.Z and the remodeling complex MYS-1/ESA1-SSL-1/SWR1 synergize with the FoxA transcription factor PHA-4 to coordinate temporal gene expression during foregut development. We observe dramatic genetic interactions between pha-4 and htz-1, mys-1, and ssl-1. A survey of transcription factors reveals that this interaction is specific, and thus pha-4 is acutely sensitive to reductions in these three proteins. Using a nuclear spot assay to visualize HTZ-1 in living embryos as organogenesis proceeds, we show that HTZ-1 is recruited to foregut promoters at the time of transcriptional onset, and this recruitment requires PHA-4. Loss of htz-1 by RNAi is lethal and leads to delayed expression of a subset of foregut genes. Thus, the effects of PHA-4 on temporal regulation can be explained in part by recruitment of HTZ-1 to target promoters. We suggest PHA-4 and HTZ-1 coordinate temporal gene expression by modulating the chromatin environment. | lld:pubmed |
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| pubmed-article:17009877 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17009877 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17009877 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17009877 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17009877 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17009877 | pubmed:issn | 1553-7404 | lld:pubmed |
| pubmed-article:17009877 | pubmed:author | pubmed-author:MangoSusan... | lld:pubmed |
| pubmed-article:17009877 | pubmed:author | pubmed-author:UpdikeDustin... | lld:pubmed |
| pubmed-article:17009877 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17009877 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:17009877 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:17009877 | pubmed:owner | NLM | lld:pubmed |
