Linked Life Data

17007937

Source:http://linkedlifedata.com/resource/pubmed/id/17007937

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pubmed-article:17007937pubmed:abstractTextNegative affect plays a crucial role in the psychopathology of schizophrenia. Although it is known that negative emotion has a strong effect on cognitive performance, this interaction has mainly been studied in healthy volunteers. Hence, working memory was assessed in 24 schizophrenia patients and 24 matched comparison subjects with a 0-back/2-back continuous performance test. Simultaneously, negative emotion was induced by olfactory stimulation. Although subjective ratings confirmed that stimulation with a negative odor was associated with a significant increase in negative affect in patients and healthy volunteers, working memory performance was affected differentially in healthy volunteers and schizophrenia patients. Whilst a similar trend of a reduced behavioral performance during negative odor stimulation was observed in patients, only controls demonstrated a significantly higher response time and a reduced number of correct reactions during higher working memory demands (2-back). Patients, on the other hand, revealed an increase in false alarms during both conditions. The present data indicate a differential effect of negative mood induction on working memory performance in schizophrenia patients and healthy subjects.lld:pubmed
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pubmed-article:17007937pubmed:dateRevised2008-4-17lld:pubmed
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pubmed-article:17007937pubmed:articleTitleInteraction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task.lld:pubmed
pubmed-article:17007937pubmed:affiliationDepartment of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. fschneider@ukaachen.delld:pubmed
pubmed-article:17007937pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17007937pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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