| pubmed-article:17001349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0218349 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0812241 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17001349 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17001349 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17001349 | pubmed:dateCreated | 2007-3-22 | lld:pubmed |
| pubmed-article:17001349 | pubmed:abstractText | Mutational activation of BRAF is a frequent event in human malignant melanomas suggesting that BRAF-dependent signaling is conducive to melanoma cell growth and survival. Previously published work reported that melanoma cells exhibit constitutive anti-apoptotic nuclear factor kappaB (NF-kappaB) transcription factor activation triggered by proteolysis of its inhibitor IkappaB. IkappaB degradation is dependent upon its phosphorylation by the IkappaB kinase (IKK) complex and subsequent ubiquitination facilitated by beta-Trcp E3 ubiquitin ligase. Here, we report that melanocytes expressing a conditionally oncogenic form of BRAF(V600E) exhibit enhanced beta-Trcp expression, increased IKK activity and a concomitant increase in the rate of IkappaBalpha degradation. Conversely, inhibition of BRAF signaling using either a broad-spectrum Raf inhibitor (BAY 43-9006) or by selective knock-down of BRAF(V600E) expression by RNA interference in human melanoma cells leads to decreased IKK activity and beta-Trcp expression, stabilization of IkappaB, inhibition of NF-kappaB transcriptional activity and sensitization of these cells to apoptosis. Taken together, these data support a model in which mutational activation of BRAF in human melanomas contributes to constitutive induction of NF-kappaB activity and to increased survival of melanoma cells. | lld:pubmed |
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| pubmed-article:17001349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17001349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17001349 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17001349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17001349 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17001349 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:LiuJJ | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:HerlynMM | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:YuDD | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:McMahonMM | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:FuchsS YSY | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:Thomas-Tikhon... | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:Suresh... | lld:pubmed |
| pubmed-article:17001349 | pubmed:author | pubmed-author:MoltonS ASA | lld:pubmed |
| pubmed-article:17001349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17001349 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:17001349 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17001349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17001349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17001349 | pubmed:pagination | 1954-8 | lld:pubmed |
| pubmed-article:17001349 | pubmed:dateRevised | 2011-3-18 | lld:pubmed |
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| pubmed-article:17001349 | pubmed:meshHeading | pubmed-meshheading:17001349... | lld:pubmed |
| pubmed-article:17001349 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17001349 | pubmed:articleTitle | Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells. | lld:pubmed |
| pubmed-article:17001349 | pubmed:affiliation | Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6046, USA. | lld:pubmed |
| pubmed-article:17001349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17001349 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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