| pubmed-article:16987657 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16987657 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:16987657 | lifeskim:mentions | umls-concept:C2266853 | lld:lifeskim |
| pubmed-article:16987657 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16987657 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:16987657 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16987657 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:16987657 | pubmed:dateCreated | 2006-11-10 | lld:pubmed |
| pubmed-article:16987657 | pubmed:abstractText | Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in clinical trials. A structurally novel series of HDAC inhibitors based on the natural cyclic tetrapeptide Apicidin is described. Selected screening of the sample collection looking for L-2-amino-8-oxodecanoic acid (L-Aoda) derivatives identified a small acyclic lead molecule 1 with the unusual ketone zinc binding group. SAR studies around this lead resulted in optimization to potent, low molecular weight, selective, non-hydroxamic acid HDAC inhibitors, equipotent to current clinical candidates. | lld:pubmed |
| pubmed-article:16987657 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16987657 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16987657 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16987657 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16987657 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16987657 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16987657 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:SteinkühlerCh... | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:AltamuraSergi... | lld:pubmed |
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| pubmed-article:16987657 | pubmed:author | pubmed-author:MeinkePeter... | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:ChakravartyPr... | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:RowleyMichael... | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:JonesPhilipP | lld:pubmed |
| pubmed-article:16987657 | pubmed:author | pubmed-author:PetrocchiAles... | lld:pubmed |
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| pubmed-article:16987657 | pubmed:author | pubmed-author:SerafiniSergi... | lld:pubmed |
| pubmed-article:16987657 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16987657 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16987657 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16987657 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16987657 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16987657 | pubmed:pagination | 5948-52 | lld:pubmed |
| pubmed-article:16987657 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16987657 | pubmed:meshHeading | pubmed-meshheading:16987657... | lld:pubmed |
| pubmed-article:16987657 | pubmed:meshHeading | pubmed-meshheading:16987657... | lld:pubmed |
| pubmed-article:16987657 | pubmed:meshHeading | pubmed-meshheading:16987657... | lld:pubmed |
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| pubmed-article:16987657 | pubmed:meshHeading | pubmed-meshheading:16987657... | lld:pubmed |
| pubmed-article:16987657 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16987657 | pubmed:articleTitle | A series of novel, potent, and selective histone deacetylase inhibitors. | lld:pubmed |
| pubmed-article:16987657 | pubmed:affiliation | IRBM/Merck Research Laboratories, Via Pontina km 30,600, 00040 Pomezia, Italy. philip_jones@merck.com <philip_jones@merck.com> | lld:pubmed |
| pubmed-article:16987657 | pubmed:publicationType | Journal Article | lld:pubmed |
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