| pubmed-article:16985254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0034821 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:16985254 | lifeskim:mentions | umls-concept:C0597513 | lld:lifeskim |
| pubmed-article:16985254 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16985254 | pubmed:dateCreated | 2007-2-6 | lld:pubmed |
| pubmed-article:16985254 | pubmed:abstractText | Steroid hormones are synthesized using cholesterol as precursor. To determine the functional importance of the low density lipoprotein (LDL) receptor and hormone-sensitive lipase (HSL) in adrenal steroidogenesis, adrenal cells were isolated from control, HSL(-/-), LDLR(-/-), and double LDLR/HSL(-/-) mice. The endocytic and selective uptake of apolipoprotein E-free human high density lipoprotein (HDL)-derived cholesteryl esters did not differ among the mice, with selective uptake accounting for >97% of uptake. In contrast, endocytic uptake of either human LDL- or rat HDL-derived cholesteryl esters was reduced 80-85% in LDLR(-/-) and double-LDLR/HSL(-/-) mice. There were no differences in the selective uptake of either human LDL- or rat HDL-derived cholesteryl esters among the mice. Maximum corticosterone production induced by ACTH or dibutyryl cyclic AMP and lipoproteins was not altered in LDLR(-/-) mice but was reduced 80-90% in HSL(-/-) mice. Maximum corticosterone production was identical in HSL(-/-) and double-LDLR/HSL(-/-) mice. These findings suggest that, although the LDL receptor is responsible for endocytic delivery of cholesteryl esters from LDL and rat HDL to mouse adrenal cells, it appears to play a negligible role in the delivery of cholesterol for acute adrenal steroidogenesis in the mouse. In contrast, HSL occupies a vital role in adrenal steroidogenesis because of its link to utilization of selectively delivered cholesteryl esters from lipoproteins. | lld:pubmed |
| pubmed-article:16985254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16985254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16985254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16985254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16985254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16985254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16985254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16985254 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16985254 | pubmed:issn | 0193-1849 | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:IshibashiShun... | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:KraemerFredri... | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:AzharSalmanS | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:ShenWen-JunWJ | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:PatelShailjaS | lld:pubmed |
| pubmed-article:16985254 | pubmed:author | pubmed-author:OsugaJun-Ichi... | lld:pubmed |
| pubmed-article:16985254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16985254 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:16985254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16985254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16985254 | pubmed:pagination | E408-12 | lld:pubmed |
| pubmed-article:16985254 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16985254 | pubmed:meshHeading | pubmed-meshheading:16985254... | lld:pubmed |
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| pubmed-article:16985254 | pubmed:meshHeading | pubmed-meshheading:16985254... | lld:pubmed |
| pubmed-article:16985254 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16985254 | pubmed:articleTitle | The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. | lld:pubmed |
| pubmed-article:16985254 | pubmed:affiliation | Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. fbk@stanford.edu | lld:pubmed |
| pubmed-article:16985254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16985254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16985254 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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