| pubmed-article:16982865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0026682 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C1155263 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16982865 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:16982865 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16982865 | pubmed:dateCreated | 2006-9-19 | lld:pubmed |
| pubmed-article:16982865 | pubmed:abstractText | The development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells. How effector T cell responses are regulated once these cell populations are established remains unclear. The recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses. In this study, we report the phenotype of the TIM-2 gene-deficient mouse, and demonstrate exacerbated lung inflammation in an airway atopic response model. Immune responses in the TIM-2-deficient mouse reveal disregulated expression of Th2 cytokines, and adoptive transfer experiments show that the T cell compartment is responsible for the heightened inflammatory phenotype. These studies show that TIM-2 is a novel and critical regulator of effector T cell activity. | lld:pubmed |
| pubmed-article:16982865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16982865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16982865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16982865 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16982865 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:BonventreJose... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:RennertPaul... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:PabloLourdesL | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:LiZhifangZ | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:BaillyVeroniq... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:IchimuraTakah... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:RennardRachel... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:TarilonteLeti... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:SizingIrene... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:McCoonPatrici... | lld:pubmed |
| pubmed-article:16982865 | pubmed:author | pubmed-author:MiklaszSteven... | lld:pubmed |
| pubmed-article:16982865 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16982865 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16982865 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16982865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16982865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16982865 | pubmed:pagination | 4311-21 | lld:pubmed |
| pubmed-article:16982865 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16982865 | pubmed:meshHeading | pubmed-meshheading:16982865... | lld:pubmed |
| pubmed-article:16982865 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16982865 | pubmed:articleTitle | T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. | lld:pubmed |
| pubmed-article:16982865 | pubmed:affiliation | Biogen-Idec, 12 Cambridge Center, Cambridge, MA 01746, USA. paul.rennert@biogenidec.com | lld:pubmed |
| pubmed-article:16982865 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16982865 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:171284 | entrezgene:pubmed | pubmed-article:16982865 | lld:entrezgene |
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