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pubmed-article:16980601pubmed:abstractTextThere is now increasing evidence that a constitutive expression of cyclooxygenase (COX)-2 plays a role in the development and progression of malignant epithelial tumors. Expression of COX-2 is seen in 93% of melanomas, as determined by immunohistochemistry. Temozolomide (TMZ) has demonstrated activity against melanoma and has been investigated as single agent or in combination. We designed a phase II study to assess the efficacy and toxicity of the combination of TMZ and celecoxib (a COX-2 inhibitor) in patients with advanced melanoma.lld:pubmed
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pubmed-article:16980601pubmed:articleTitleTemozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group.lld:pubmed
pubmed-article:16980601pubmed:affiliationFirst Department of Medicine, University of Athens, Medical School, Athens, Greece. hgogas@hol.grlld:pubmed
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pubmed-article:16980601pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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