| pubmed-article:16946018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C1411976 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C1424783 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16946018 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16946018 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16946018 | pubmed:dateCreated | 2006-12-1 | lld:pubmed |
| pubmed-article:16946018 | pubmed:abstractText | The cell surface receptor complex formed by TLR4 and myeloid differentiation 2 (MD-2) is engaged when cells are exposed to LPS. Recent studies suggested that surface localization of functional mouse TLR4 (mTLR4) depends on the simultaneous expression of MD-2. As we did not observe a similar requirement, we conducted a comparative study of human TLR4 and mTLR4 surface expression in immune cells derived from the MD-2 knockout mouse and LPS-responsive cell lines and in cells that ectopically express TLR4. Our results indicate that in the human and mouse models, neither TLR4 function nor TLR4 surface targeting requires MD-2 coexpression. Accordingly, we report on one human cell line, which constitutively expresses functional TLR4 on the cell surface in the absence of MD-2 expression. | lld:pubmed |
| pubmed-article:16946018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16946018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16946018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16946018 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16946018 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:GolenbockDoug... | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:VisintinAlber... | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:LienEgilE | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:MonksBrian... | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:KhanNaseemaN | lld:pubmed |
| pubmed-article:16946018 | pubmed:author | pubmed-author:HalmenKristen... | lld:pubmed |
| pubmed-article:16946018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16946018 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16946018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16946018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16946018 | pubmed:pagination | 1584-92 | lld:pubmed |
| pubmed-article:16946018 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:meshHeading | pubmed-meshheading:16946018... | lld:pubmed |
| pubmed-article:16946018 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16946018 | pubmed:articleTitle | MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). | lld:pubmed |
| pubmed-article:16946018 | pubmed:affiliation | Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, NRB, 370L, 364 Plantation Street, Worcester, MA 01605, USA. alberto.visintin@umassmed.edu | lld:pubmed |
| pubmed-article:16946018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16946018 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16946018 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:21898 | entrezgene:pubmed | pubmed-article:16946018 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16946018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16946018 | lld:pubmed |
