| pubmed-article:16932990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0003662 | lld:lifeskim |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0339573 | lld:lifeskim |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0019878 | lld:lifeskim |
| pubmed-article:16932990 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:16932990 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16932990 | pubmed:dateCreated | 2007-3-23 | lld:pubmed |
| pubmed-article:16932990 | pubmed:abstractText | We determined homocysteine (Hcy) levels in aqueous humor (AH) and plasma and their association with B-vitamin levels in patients with primary open-angle glaucoma (POAG) and controls. Both AH Hcy and plasma Hcy levels were significantly increased in POAG, and elevation of AH Hcy and plasma Hcy was a significant risk factor for POAG. In contrast to controls, neither plasma nor AH Hcy of POAG patients demonstrated a significant association with important non-genetic determinants of elevated Hcy such as low B-vitamin levels, increasing age and caffeine consumption. Considering that Hcy is a neurotoxin that induces apoptotic retinal ganglion cell death via stimulation of the N-methyl-D-asparate (NMDA) receptor, increased Hcy concentrations in AH and plasma might contribute to the optic nerve damage in POAG. | lld:pubmed |
| pubmed-article:16932990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16932990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16932990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16932990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16932990 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:KornhuberJJ | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:Schlötzer-Sch... | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:KruseF EFE | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:BleichSS | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:von AhsenNN | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:RejdakRR | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:ReulbachUU | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:NaumannG O... | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:RoedlJ BJB | lld:pubmed |
| pubmed-article:16932990 | pubmed:author | pubmed-author:JünemannA G... | lld:pubmed |
| pubmed-article:16932990 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16932990 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:16932990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16932990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16932990 | pubmed:pagination | 445-50 | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:meshHeading | pubmed-meshheading:16932990... | lld:pubmed |
| pubmed-article:16932990 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16932990 | pubmed:articleTitle | Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma. | lld:pubmed |
| pubmed-article:16932990 | pubmed:affiliation | Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander-University, Erlangen-Nuremberg, Germany. | lld:pubmed |
| pubmed-article:16932990 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16932990 | lld:pubmed |
