| pubmed-article:1691678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1691678 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:1691678 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:1691678 | lifeskim:mentions | umls-concept:C1751130 | lld:lifeskim |
| pubmed-article:1691678 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1691678 | pubmed:dateCreated | 1990-5-29 | lld:pubmed |
| pubmed-article:1691678 | pubmed:abstractText | The effects of the peripheral-type benzodiapine receptor (PBR) ligands Ro 5-4864 and PK 11195 were studied in the spontaneously beating guinea pig atrium and in a model for myocardial ischemia in the rat. In the former, Bay K 8644 produced positive chronotropic and inotropic responses; intracarotid administration of this agonist (5 or 10 micrograms kg-1) to anesthetized rats elicited a transient increase in mean arterial blood pressure accompanied by alterations in the ECG pattern. Ro 5-4864 and PK 11195 (10 microM) completely blocked the positive chronotropic effect of Bay K 8644 in the atrium, PK 11209, a structural analog of PK 11195 with a low affinity for PBR, was inactive, and the central benzodiazepine receptor ligand clonazepam had a marginal effect. Ro 5-4864 potentiated whereas PK 11195 inhibited the myocardial ischemia produced by Bay K 8644 in the rat. Furthermore, PK 11195 blocked the combined response to Bay K 8644 and Ro 5-4864. Addition of Ro 5-4864 (10 microM) to the organ bath potentiated the inotropic effect of Bay K 8644 in the atria; PK 11195 at the same concentration inhibited this effect. Clonazepam and PK 11209 were both inactive in this regard. Nifedipine, a potent calcium channel antagonist, completely blocked the inotropic and chronotropic responses to Bay K 8644. PK 11195 and Ro 5-4864 did not affect this action. These findings strongly suggest that there is a functional association between PBR and voltage-operated calcium channels in the guinea pig atrium and rat cardiovascular system. | lld:pubmed |
| pubmed-article:1691678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1691678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1691678 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1691678 | pubmed:issn | 0008-4212 | lld:pubmed |
| pubmed-article:1691678 | pubmed:author | pubmed-author:AbrahamSS | lld:pubmed |
| pubmed-article:1691678 | pubmed:author | pubmed-author:WeissmanB ABA | lld:pubmed |
| pubmed-article:1691678 | pubmed:author | pubmed-author:HOUH CHC | lld:pubmed |
| pubmed-article:1691678 | pubmed:author | pubmed-author:BolgerG TGT | lld:pubmed |
| pubmed-article:1691678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1691678 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:1691678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1691678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1691678 | pubmed:pagination | 40-5 | lld:pubmed |
| pubmed-article:1691678 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1691678 | pubmed:meshHeading | pubmed-meshheading:1691678-... | lld:pubmed |
| pubmed-article:1691678 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1691678 | pubmed:articleTitle | Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels. | lld:pubmed |
| pubmed-article:1691678 | pubmed:affiliation | Division of Basic Medical Sciences, Memorial University of Newfoundland, St. John's, Canada. | lld:pubmed |
| pubmed-article:1691678 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1691678 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1691678 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1691678 | lld:pubmed |
