| pubmed-article:1690821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C1979927 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:1690821 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1690821 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1690821 | pubmed:dateCreated | 1990-5-3 | lld:pubmed |
| pubmed-article:1690821 | pubmed:abstractText | We recently found (C. Devaux, J. Boucraut, G. Poirier, P. Corbeau, F. Rey, M. Benkirane, B. Perarneau, F. Kourilsky, and J.C. Chermann, submitted for publication) a latency in the human immunodeficiency virus (HIV) type 1 cytopathic effect in the human T-cell lymphotropic virus type I immortalized T-cell line MT4 that was mediated by anti-beta 2 microglobulin (beta 2m) monoclonal antibodies (MAb). Here we describe a delay in viral particle production in peripheral blood mononuclear cells (PBMC) that was mediated by three (B1-1G6, B2-62-2, and HC11-151-1) of four anti-beta 2m MAb tested, the nonefficient MAb (C21-48A) being specific for an epitope on beta 2m that was masked by association with the human leukocyte antigen class I heavy chain. Experiments were designed to determine the mechanism of interference. PBMC incubated with anti-beta 2m MAb before viral exposure were not protected from HIV infection. In addition, anti-beta 2m MAb were not efficient in preventing syncytium formation between HIV-infected PBMC and CD4-positive MT4 cells. In contrast, anti-beta 2m MAb treatment of freshly infected PBMC significantly delayed HIV production in these cells. The window of cell sensitivity to anti-beta 2m MAb treatment took place during a very early post-HIV-binding stage. The possible mechanism of anti-beta 2m MAb action is discussed. | lld:pubmed |
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| pubmed-article:1690821 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1690821 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690821 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1690821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1690821 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1690821 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1690821 | pubmed:author | pubmed-author:DevauxCC | lld:pubmed |
| pubmed-article:1690821 | pubmed:author | pubmed-author:ChermannJ CJC | lld:pubmed |
| pubmed-article:1690821 | pubmed:author | pubmed-author:KourilskyFF | lld:pubmed |
| pubmed-article:1690821 | pubmed:author | pubmed-author:CorbeauPP | lld:pubmed |
| pubmed-article:1690821 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1690821 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:1690821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1690821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1690821 | pubmed:pagination | 1459-64 | lld:pubmed |
| pubmed-article:1690821 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1690821 | pubmed:meshHeading | pubmed-meshheading:1690821-... | lld:pubmed |
| pubmed-article:1690821 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1690821 | pubmed:articleTitle | An early postinfection signal mediated by monoclonal anti-beta 2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 in peripheral blood mononuclear cells. | lld:pubmed |
| pubmed-article:1690821 | pubmed:affiliation | Unité de Recherches sur les Rétrovirus et Maladies Associées, Institut National de la Santé, Marseille, France. | lld:pubmed |
| pubmed-article:1690821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1690821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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