| pubmed-article:16898500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16898500 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:16898500 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:16898500 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:16898500 | lifeskim:mentions | umls-concept:C0268800 | lld:lifeskim |
| pubmed-article:16898500 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:16898500 | pubmed:dateCreated | 2006-8-10 | lld:pubmed |
| pubmed-article:16898500 | pubmed:abstractText | Autosomal dominant polycystic disease is characterised by abnormal polycystin, protein, which is a component of basement membrane and extracellular matrix. Transforming growth factor (TGF-beta1) is a cytokine, which takes part in development of renal tubule epithelium and stimulates the synthesis of extracellular matrix proteins. The aim of work was the assessment of TGF-beta1 concentration in children with renal polycystic disease. MATERIAL AND METHODS: The examined group (I) consisted of 33 children aged (median 14.7 years, range 4.0-17.9): A--11 children with solitary cyst, B--22 with polycystic renal disease. Control group (C) consisted of 20 healthy children at the same age. The concentration of urinary TGF-b1 was measured using immunoenzymatic ELISA method. The results showed that mean concentration of urinary TGF-beta 1 (121.9 +/- 168 pg/mg cr.) was lower than in group B, in which it was 207.2 +/- 361 pg/mg cr. However the difference was not statistically significant (p>0.05). In both subgroups (A and B) urinary excretion of TGF-beta1 was higher than in control group (C) (p<0.05). In 4 (36%) children from group A and 8 (36%) from group B the urinary concentration of TGF-beta 1 was below the sensitivity of the method. No correlation between TGF-beta 1 and children's age, urinary osmolality and GRF according to Schwartz was found. It was a positive correlation between urinary TGF-betal concentration and total diameter of renal cysts. CONCLUSIONS: TGF-betal takes part in renal cyst formation and increased urinary excretion of TGF-b1 in proportion to the dimension of renal cysts may be an evidence of that fact. | lld:pubmed |
| pubmed-article:16898500 | pubmed:language | pol | lld:pubmed |
| pubmed-article:16898500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16898500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16898500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16898500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16898500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16898500 | pubmed:issn | 0033-2240 | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:WasilewskaAnn... | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:PorowskiTadeu... | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:BiernackaAnna... | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:NiewiarowskaA... | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:Zoch-ZwierzWa... | lld:pubmed |
| pubmed-article:16898500 | pubmed:author | pubmed-author:TenderendaEdy... | lld:pubmed |
| pubmed-article:16898500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16898500 | pubmed:volume | 63 Suppl 3 | lld:pubmed |
| pubmed-article:16898500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16898500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16898500 | pubmed:pagination | 94-6 | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:meshHeading | pubmed-meshheading:16898500... | lld:pubmed |
| pubmed-article:16898500 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16898500 | pubmed:articleTitle | [Urinary TGF-beta1 excretion in children with renal cysts]. | lld:pubmed |
| pubmed-article:16898500 | pubmed:affiliation | I Klinika Chorób Dzieci Akademii Medycznej w Bia?ymstoku. | lld:pubmed |
| pubmed-article:16898500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16898500 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16898500 | pubmed:publicationType | English Abstract | lld:pubmed |
