| pubmed-article:16888287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16888287 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16888287 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16888287 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:16888287 | lifeskim:mentions | umls-concept:C2610574 | lld:lifeskim |
| pubmed-article:16888287 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:16888287 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16888287 | pubmed:dateCreated | 2006-12-14 | lld:pubmed |
| pubmed-article:16888287 | pubmed:abstractText | Pulmonary inflammation and increased production of the inflammatory cytokine IL-1beta are associated with the development of bronchopulmonary dysplasia (BPD) in premature infants. To study the actions of IL-1beta in the fetal and newborn lung in vivo, we developed a bitransgenic mouse in which IL-1beta is expressed under conditional control in airway epithelial cells. Perinatal pulmonary expression of IL-1beta caused respiratory insufficiency that was associated with increased postnatal mortality. While intrauterine growth of IL-1beta-expressing mice was normal, their postnatal growth was impaired. IL-1beta disrupted alveolar septation and caused abnormalities in alpha-smooth muscle actin and elastin deposition in the septa of distal airspaces. IL-1beta disturbed capillary development and inhibited the production of vascular endothelial growth factor in the lungs of infant mice. IL-1beta induced the expression of CXC chemokines KC (CXCL1) and macrophage inflammatory protein-2 (CXCL2) and of CC chemokines monocyte chemotactic protein (MCP)-1 (CCL2) and MCP-3 (CCL7), consistent with neutrophilic and monocytic infiltration of the lungs. IL-1beta caused goblet cell metaplasia and bronchial smooth muscle hyperplasia. Perinatal expression of IL-1beta in epithelial cells of the lung caused a lung disease that was clinically and histologically similar to BPD. | lld:pubmed |
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| pubmed-article:16888287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16888287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16888287 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16888287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16888287 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16888287 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:16888287 | pubmed:author | pubmed-author:WhitsettJeffr... | lld:pubmed |
| pubmed-article:16888287 | pubmed:author | pubmed-author:LappalainenUr... | lld:pubmed |
| pubmed-article:16888287 | pubmed:author | pubmed-author:BryKristinaK | lld:pubmed |
